APOE and Alzheimer disease: Previous studies using both survival analyses and linear mixed effect models showed improved prediction of AD progression by combining MRI data with CSF biomarkers (Vemuri et al., 2009; Westman et al., 2012), APOE genotype (McEvoy et al., 2009; Dukart et al., 2015), and different cognitive test batteries (Callahan et al., 2015; Eckerström et al., 2015; Li et al., 2016).