MiR-210 was with the highest connectivity with target genes, targeting 12 differentially expressed genes (ANGPTL4, AQP1, ARHGAP25, BTG2, CD247, DNASE1L3, LYL1, P2RY8, SH2D3C, SRL, STAT5A, TNFRSF1B), that might indicate its important role in osteosarcoma. This evidence concerns the gene LYL1 and osteosarcoma.