To investigate how hyperglycemia affects kidney function, plasma creatinine levels were analyzed and showed no difference between the ApoE−/− mice (148 μmol/L, IQR 106.4–204.7) and the ApoE−/− GK+/− mice (125 μmol/L, 72.7–146.6). The gene discussed is GK; the disease is Hyperglycemia.