In addition to the more immediate connections previously recognised (COL5A1—classical EDS, ZNF469—brittle cornea syndrome, COL8A2—Fuchs endothelial dystrophy), AGBL1—a Fuchs endothelial dystrophy gene21—is 784 kb away from rs4843040 on chr15q25.3, and SMAD3 is a Loeys-Dietz connective tissue syndrome gene. The gene discussed is AGBL1; the disease is Fuchs' endothelial dystrophy.