Of the 36 CCT SNPs tested for association with disease risk in the keratoconus studies, three were significant and with the expected direction of effect (rs66720556 between MPDZ-NFIB, rs3132303 between RXRA-COL5A1, and rs2755238 close to FOXO1). The gene discussed is COL5A1; the disease is keratoconus.