For example, knockout mouse models available for these genes have shown a variety of cornea-related phenotypes, including thin corneal stroma (FBN1, KERA, LUM, TGFB2)27–32, corneal opacity (LUM)30–32, absence of corneal endothelium (TGFB2)27, delayed corneal endothelium maturation and increased thickness (COL12A1)33. This evidence concerns the gene COL12A1 and Corneal opacity.