Overall, we found a significant negative correlation of effect sizes across CCT and keratoconus (r = −0.62, P = 5.30 × 10−5) (Fig. 2a, Supplementary Table 4), this correlation was largely unchanged if the known SNPs in ZNF469, FOXO1, COL5A1 and MPDZ/NFIB were removed from the analysis (r = −0.61, P = 2.04 × 10−4). The gene discussed is COL5A1; the disease is keratoconus.