For example, knockout mouse models available for these genes have shown a variety of cornea-related phenotypes, including thin corneal stroma (FBN1, KERA, LUM, TGFB2)27–32, corneal opacity (LUM)30–32, absence of corneal endothelium (TGFB2)27, delayed corneal endothelium maturation and increased thickness (COL12A1)33. The gene discussed is FBN1; the disease is Corneal opacity.