Finally, three connective tissues disease genes harboured lead SNPs for new CCT loci, ADAMTS2 (intronic lead SNP rs35028368) involved in EDS, type VIIC (OMIM: 225410), FBN1 (intronic lead SNP rs8030753) the Marfan syndrome major gene (OMIM: 154700), and TGFB2 (intronic lead SNP rs4846476) a Loeys-Dietz syndrome gene. Here, ADAMTS2 is linked to Loeys-Dietz syndrome.