LUM and Corneal opacity: For example, knockout mouse models available for these genes have shown a variety of cornea-related phenotypes, including thin corneal stroma (FBN1, KERA, LUM, TGFB2)27–32, corneal opacity (LUM)30–32, absence of corneal endothelium (TGFB2)27, delayed corneal endothelium maturation and increased thickness (COL12A1)33.