CD82 and pancreatic ductal adenocarcinoma: Furthermore, CD82 interacts with: (i) p12CDK2-AP1 to regulate the proliferation and survival of human oral squamous cell carcinoma cells57, (ii) DARC to maintain quiescence in long-term repopulation of hematopoietic stem cells58, and (iii) tissue inhibitor of metalloproteinases-1 (TIMP-1), where the proteins colocalize in both pancreatic ductal adenocarcinoma cell lines and clinical samples.