RUNX1 and pulmonary tuberculosis: Interestingly, when we examined pulmonary RUNX1 expression between healthy controls and patients with pulmonary TB, we found weak positivity in the nuclei of bronchiole epithelial cells, pneumocytes, and alveolar macrophages in blood vessels of normal lung parenchyma, whereas cases of pulmonary TB exhibited strong positivity in lymphocytes, epithelioid cells, and multinucleated giant cells in granulomas (Fig. 6e).