Although evidence supporting a genetic association of PACRG mutation and PD has not been reported26, the protein has been shown to be a component of Lewy bodies in PD27,28 and steady state levels of parkin and PACRG have been shown to be inversely correlated with alpha-synuclein accumulation in the astrocytes of individuals with PD29. This evidence concerns the gene PACRG and Parkinson disease.