In addition, ZNF382 expression was analysed using the online Gene Expression across Normal and Tumour (GENT) tissue database (http://medical-genome.kribb.re.kr/GENT/search/search.php), and ZNF382 was also found to be downregulated in ESCC tissues compared with normal oesophageal epithelial tissues (Fig. 1d, p= 0.0016). This evidence concerns the gene ZNF382 and esophageal squamous cell carcinoma.