Moreover, these significantly regulated genes identified in both KYSE150 and KYSE410 cells were involved in cell metastasis (SLUG, SNAIL and SMAD3), cell growth (CSF1 and VEGFA), stress-induced protector (SESN3) and stem cell regulation (SOX2 and STAT5B), adding to our understanding of the possible mechanisms of ZNF382 tumour suppression in ESCC. This evidence concerns the gene SNAI1 and esophageal squamous cell carcinoma.