Moreover, these significantly regulated genes identified in both KYSE150 and KYSE410 cells were involved in cell metastasis (SLUG, SNAIL and SMAD3), cell growth (CSF1 and VEGFA), stress-induced protector (SESN3) and stem cell regulation (SOX2 and STAT5B), adding to our understanding of the possible mechanisms of ZNF382 tumour suppression in ESCC. The gene discussed is VEGFA; the disease is esophageal squamous cell carcinoma.