We recently showed that IL-1R1 antagonist Anakinra reduces the number of microvessels in sub-cutaneous breast tumours and bone metastases caused by the osteotrophic triple-negative breast cancer cell line MDA-MB-231-IV, after both a preventative and treatment strategy (Fig. 3) (Holen et al. 2016a). This evidence concerns the gene IL1R1 and breast neoplasm.