ELF3 and esophageal adenocarcinoma: For instance, the W30R in EKLF4 (allele frequency in the human population of 1.3 × 10−5; gnomAD database) and the E135K mutation in ESX, which is prevalent in esophageal adenocarcinoma (allele frequency of 0.37 from cBioPortal), may lead to loss of TAD activity in these transcription factors (Appendix Fig S10).