In common with the regulation of other bHLH proneural genes (Ali et al., 2011, 2014; Azzarelli et al., 2017; Hardwick and Philpott, 2015; Hindley et al., 2012), additional phosphorylation events potentially mediated by CDKs may play a more widespread role in controlling Atoh1 activity in both normal granule neuron precursors and in medulloblastoma. The gene discussed is ATOH1; the disease is medulloblastoma.