APOE and Alzheimer disease: Among such significant associations, the ApoE haplotype E3E3 combined with the rs3810950 genotype AA and the ApoE haplotype E3E4 combined with the rs3810950 genotype GG displayed the greatest risk of AD with risk ratios (RR) 1.54 (p = 0.001) and 1.52 (P < 0.0001), resp.