In two longitudinal studies of overweight or obese youth, reductions in RBP4 were reported to accompany weight loss, improvement of triglyceride (TG) levels and IR [18, 19], while a small study of Korean boys reported that baseline RBP4 levels did not predict the development of MS over a 3-year follow-up [20]. This evidence concerns the gene RBP4 and myeloid sarcoma.