With respect to the key elements of MS, after adjusting for age, gender and puberty (Model 1, Table 4), RBP4 levels at baseline predicted IR (OR per 10 μg/ml (approximately 1 SD) increase 1.42, [95% CI = 1.08–1.86], P = 0.011), hyperglycemia (OR 1.49, [95% CI 1.11–1.99], P = 0.008), elevated blood pressure (OR 1.38, [95% CI = 1.07–1.76], P = 0.012) and elevated TG (OR 1.83, [95% CI = 1.40–2.41], P = 0.004) at follow-up. Here, RBP4 is linked to Hyperglycemia.