As IR predisposes one to develop T2D, we found that subjects with the highest levels of RBP4 in childhood had the greatest risks of developing hyperglycemia during the 10-years follow-up phase, although there was a very low incidence of T2D after just 10 years of follow-up (at a mean age of 20.2). This evidence concerns the gene RBP4 and Hyperglycemia.