ENTPD3 and colitis: POM‐1 inhibits phosphohydrolysis of ATP by selectively targeting NTPDases, especially NTPDase1 and NTPDase3, both overexpressed in human inflamed intestinal mucosa (Figure 1b).35 It has been reported that global deficiency of NTPDase1 or NTPDase3 resulted in exacerbation of DSS colitis.9, 36 DSS administration induced similar body weight loss in both control and POM‐1‐treated mice.