ADORA2A and inflammatory bowel disease: These results are consistent with a previous study showing that IBD patients have more IL‐22‐producing ILC3s in colonic mucosa than control individuals.33 Interestingly, in the mucosal tissue of inflamed colons there was a positive correlation between expression of ENTPD1 and ADORA2A genes, and both genes positively correlated with ILC3‐signature genes (e.g. IL7R and NRP1) in active UC colon biopsies (Figure 1e).