These results are consistent with a previous study showing that IBD patients have more IL‐22‐producing ILC3s in colonic mucosa than control individuals.33 Interestingly, in the mucosal tissue of inflamed colons there was a positive correlation between expression of ENTPD1 and ADORA2A genes, and both genes positively correlated with ILC3‐signature genes (e.g. IL7R and NRP1) in active UC colon biopsies (Figure 1e). Here, IL22 is linked to inflammatory bowel disease.