An intriguing study demonstrated that in each of 29 LAM lung samples studied, the mesenchymal chromatin binding protein HMGA2 was expressed along with IGF2BP2 (IMP2), a protein whose transcription is increased by HMGA2 and whose role is to stabilize IGF2 mRNA [39]. The gene discussed is IGF2BP2; the disease is lymphangioleiomyomatosis.