For the gene-environment analysis, which included age, sex, and blood pressure as the covariates, GMDR identified the five-factor interaction model of ABCA1rs1800976-ABCA1 rs4149313-LCATrs1109166-obesity-smoking as the best model for dyslipidemia, with a testing balance accuracy of 0.5313 and a maximum cross-validation consistency of 10/10 (P = 0.0107). This evidence concerns the gene ABCA1 and Obesity.