SOX7 and breast cancer: To determine whether SOX7-mediated gene expression is independent of cell lines, we tested two additional breast cancer cell lines, MDA-MB-453 and MCF-7, and found that the four potential SOX7 target genes identified in MDA-MB-231 cells also showed corresponding up- or downregulation in response to ectopically expressed SOX7 in these two cell lines (Figure S3B,C).