When combinatorially analyzing a gene array dataset from a breast cancer cohort, we identified SOX7-activated SPRY1 (sprouty homolog 1) and SLIT2 (slit guidance ligand 2) genes, and SOX7-repressed TRIB3 (Tribbles homolog 3) and MTHFD2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2) genes, and determined their roles in SOX7-mediated tumor suppression. Here, MTHFD2 is linked to breast cancer.