There were no significant associations between phospho-AKT Ser473 total expression and the following features: age, tumor size, tumor capsule, multifocality, lymphocytic infiltrate, vascular invasion, lymph node metastases, tumor margins (well circumscribed vs. infiltrative), distant metastases, staging, NRAS and TERTp status, number of 131I therapies or cumulative dose of radioactive iodine, additional treatments, disease-free status at one year, and disease-free status at the end of follow-up. This evidence concerns the gene AKT1 and neoplasm.