In addition, overexpression of caveolin-1 (CAV-1), zinc-dependent mammalian histone deacetylase (HDAC), 3-phosphoinositide-dependent protein kinase-1 (PDPK1), PG receptor EP2 and FP, prostaglandin-degrading enzyme (15-PGDH), and prostaglandin-endoperoxide synthase protein cyclooxygenase-2 (COX-2) also trigger the development of prostate cancer [13]. This evidence concerns the gene PTGS2 and Familial prostate cancer.