Members have key roles in maintaining genomic stability, with inactivation leading to cancer predisposition syndromes including Bloom’s syndrome (BLM) [207,208], Werner syndrome (WRN) [209], and in the case of RecQL4, three syndromes: Rothmund–Thomson syndrome (RTS), Baller–Gerold syndrome (BGS) and RAPADILINO [210,211]. The gene discussed is RECQL4; the disease is Bloom syndrome.