MARCKS and lung carcinoma: Chen et al. showed that an increase of phospho-MARCKS can activate lung cancer cells growth and there exists a high correlation between the phospho-MARCAS and lower survival chance for lung cancer patients, suggesting that phospho-MARCAS, which is transferred to the cytoplasm, leads to the detachment of phosphatidylinositol-4,5-bisphosphate (PIP2) from the membrane.