AKT1 and neoplasm: Apart from the influence on the viability of tumor cells, EO could affect migratory and invading properties of different tumor cells through inhibition of MMP-9, MMP-2, focal adhesion kinase (FAK), ERK1/2, and Akt/PKB activation, and partial inhibition of AP-1 and NF-kB transcriptional activities [6,14,15,16,17,18].