The central components of the FA pathway are the 13 complementation groups identified so far, i.e. Fanconi anaemia complementation group (FANC) A, FANCB, FANCC, and FANCD1 (better known as BRCA2), FANCD2, FANCE, FANCF, FANCG, FAQNCI, and FANCJ [BRCA1‐interacting protein C‐terminal helicase 1 (BRIP1) or BTB domain and CNC homologue 1 (BACH1)], and FANCL, FANCM, and FANCN [also termed partner and localizer of BRCA2 (PALB2)], which are mutated with various frequencies in FA* 92. The gene discussed is BRCA2; the disease is Fanconi anemia.