TP53 and cancer: In accordance with the main prediction of our model, p53 function was gradually attenuated, apoptosis was reduced, and a fraction of senescent cells escaped, showing aggressive traits [Figure 5(4–6); lower panel] 159, 314, 327, 342, such as increased invasiveness, aneuploidy,* and features reminiscent of EMT* 159, 314, 343, which is an embryonic developmental programme exploited by cancer cells to invade and metastasize 344, 345.