Hence, inactivation of p16INK4A–Rb signalling is not a surprising finding in cancer 221, 334, 335, 336, 337, as it releases E2F transcription factor 1 (E2F1) from its inhibitory control 329, 333, 338, 339, stimulating the sustained expression of cell‐cycle drivers such as cyclin E, Cdc6, and Cdt1, converting them into ‘oncogenic stimuli’ [Figure 5(1); lower panel] 112, 210, 314, 327, 338, 340. The gene discussed is RB1; the disease is cancer.