26 There was a highly significant association between total and HMW at baseline. Bluher et al. reported no superiority of HMW adiponectin over total adiponectin values in predicting insulin sensitivity. 27 Likewise, the study results also showed a similar magnitude of correlations between both total and HMW adiponectin levels with the HOMA score at baseline suggesting no clinical differences between total and HMW adiponectin levels in relation to insulin resistance. The gene discussed is INS; the disease is Insulin resistance.