There was significant reduction in AST and ALT level (P < 0.001 for both) after completion of the antiviral treatment which came in accordance with one previous study by Mehta et al. in 2017 who studied the safety and efficacy of Sofosbuvir and Daclatasvir for treatment of chronic hepatitis C infection in a group of patients with B-Thalassemia major. Here, GPT is linked to chronic hepatitis C virus infection.