Third PD-1L was strongly expressed on Sternberg Reed cells in the present case (Figure 2, lane d), but PD-L1 was neither amplified, translocated nor mutated although copy number alterations, amplifications [13, 14] and translocations of MHC class II transactivator CII TA with subsequent activation of PD-L1 and PD-L2 [34] are frequent in this lymphoma and associated with advanced stage and inferior outcome of first line therapy [14, 35]. This evidence concerns the gene PDCD1LG2 and lymphoma.