Over the course of the disease, seven genes were found to be altered (Table 2), with mutations in BRIP1 G212fs*62, KRAS L19F, MYC A59T, ARIDA1A E1683fs*15, KDM5A R1239W and TP53 277Y to the best of our knowledge never reported before in Hodgkin lymphoma. This evidence concerns the gene TP53 and Hodgkins lymphoma.