While this study revealed JMJD3 to be unnecessary for M1 polarization of TLR ligand-stimulated mouse peritoneal macrophages, other studies involving IFNg-stimulated HMDMs [27] or LPS + IFNγ-stimulated HMDMs from rheumatoid arthritis patients [30] detail its role in inducing pro-inflammatory cytokine expression. The gene discussed is IFNG; the disease is rheumatoid arthritis.