It is involved in the control of cell survival in PCa, partly through modulation of Androgen Receptor (AR) signaling, including the regulation of androgen-regulated genes (TMPRSS2, PSA, and FGF8) [37], It is also involved in the regulation of genes involved in processes like angiogenesis (IFNB1, COL18A1 and VEGFA), cell adhesion (MTSS1 and ITGB1), signal transduction (MAP2K1, ERBB2 and PIK3R1), apoptosis and cell senescence (TERT, BAD, and TNFRSF25), invasion and metastasis (MTA2 and PLAUR), and DNA damage repair (BRCA1). Here, KLK3 is linked to posterior cortical atrophy.