Therapies and drugs that target RNA molecules provide the basis for precision lncRNA-based cancer therapies, in particular more attention should be given in lncRNAs associated to radiotherapy and AR inhibitors such as enzatulamide (Figure 1), because their importance that has been seen in patients with high-risk localized PCa, even clinical trails studies (NCT02446444) are in development to determine the effectiveness of these therapies in the outcome of patients. The gene discussed is AR; the disease is cancer.