STAT3 and glioblastoma: [20] Overexpression of miR-9 using a mimic in CD133+ GBM stem cells promotes oligoneural and suppresses a more aggressive mesenchymal phenotype by downregulating expression of Janus kinases (JAK1 and JAK3), inhibiting activation of signal transducer and activator of transcription 3 (STAT3) and decreasing expression of the STAT3 transcriptional target CCAAT/enhancer-binding protein β (C/EBPβ) (Figure 1A).