By regulating the differentiation and maturation of dendritic cells (DCs) and their antigen-processing ability, Exo regulate immune cell activity and counteract anti-melanoma immune processes [13] while also modulate apoptosis and the survival of CD4+ and CD8+ effector T-cells (Teffs), regulatory T-cells (Treg) and myeloid-derived suppressor cells (MDSCs) [14–17]. This evidence concerns the gene CD4 and melanoma.