Recent studies of the intercellular cross-talk in melanoma demonstrated that the Exo payload is shaped by somatic evolution, as Exo from different melanoma cell lines exert variable effects on the T-cell-inhibited proliferation of the tumor cells, including via the exosomal up-regulation of the protein-tyrosine phosphatase PTPN11 [27]. The gene discussed is PTPN11; the disease is melanoma.