There were significant correlations between LINE-1 methylation level and HCV-specific antibody (HCV Ab)-positivity (p = 0.039), des-gamma-carboxy prothrombin (DCP) (p = 0.032) and F stage (p = 0.024) in HCC and between LINE-1 methylation level and tumor number in cHCC-CC (p = 0.038). Here, ACE is linked to hepatocellular carcinoma.