Recently, it was shown that the combination of rapamycin or PI3K/mTOR inhibitors and one specific RTK inhibitor (EGFR, MET or IGF1R inhibitor) suppressed adverse AKT activation and hampered mesothelioma cell growth in vitro and in MPM xenografts [7, 10, 50]. This evidence concerns the gene AKT1 and mesothelioma.