To explore the anti-tumor efficacy of simultaneous inhibition of mTOR and ALK, we (1) determined the ALK and mTOR status in eight patient-derived mesothelioma grafts and (2) assessed the effect of rapamycin and crizotinib therapy on the growth of one graft (PDX680) with demonstrated co-activation of both mTOR and ALK. This evidence concerns the gene ALK and mesothelioma.