Inhibition of mTOR by rapamycin or its derivatives (sirolimus, temsirolimus, everolimus) suppressed mesothelioma cell growth in pre-clinical models [17, 19, 20], but was not effective in clinical trials: everolimus showed no therapeutic benefit in unselected MPM patients [21] and a small group of patients selected for NF2 deletion (NCT01024946). The gene discussed is MTOR; the disease is mesothelioma.