In the Blueprint PD-L1 IHC Assay Comparison Project, the authors stained 39 cases of non-small cell lung cancer (NSCLC) using 4 PD-L1 IHC assays and reported that changing the assays and cut-off values used would lead to the misclassification of the PD-L1 status [17]. The gene discussed is CD274; the disease is non-small cell lung carcinoma.