CYCS and neoplasm: As shown in Supplementary Figure 1B, only 50% of the mice that received cytochrome c and were in the anti-PD1+Poly(I:C) therapy group were able to clear tumor whereas mice in the anti-PD1+Poly(I:C) treatment group that did not receive cytochrome c had the highest rate of tumor clearance at day 35 (79% of mice cleared tumor at day 35) (Supplementary Figure 1C).