CD274 and brain neoplasm: It is noteworthy that brain tumor infiltrating migratory DCs were found to have the highest expression of PD-L1 and PD-L2 (Supplementary Figure 2), and that treatment with anti-PD-1+poly(I:C) increased the expression of PD-L1 in myeloid cells mainly in the lymph nodes and in the spleen, and to a lesser degree in the brain tumor (Supplementary Figure 4).