Although the effects of COPS5 knock-down in SNAIL expression was most predominant amongst the candidates in lung adenocarcinomas, the other four DUBs (JOSD1, OTUB1, OTUD7A, and OTUD7B) could potentially regulate SNAIL expression in other cancer such as cervical cancers (Figure 2). Here, JOSD1 is linked to cervical carcinoma.