Overall, 111 somatic mutations targeting 73 genes were detected (median 16.5 per case, range 1–49), including 18 likely pathogenic mutations in 11 cancer genes (AKAP9, ATM, ATR, BRAF, CDH1, ERBB2, FGFR2, MLH1, PIK3CA, RAF1 and TP53, Figures 1C and 2). This evidence concerns the gene MLH1 and cancer.