Several studies suggest that cytotoxic drugs like oxaliplatin, gemcitabine, 5-FU or cyclophosphamide, mAbs to EGFR and VEGF, as well as radiotherapy, may induce immunogenic cell death, and shape mCRC micro-environmental conditions making the residual tumor tissue more sensitive to activated immune-effectors. The gene discussed is EGFR; the disease is neoplasm.