For the co-inhibitory molecules, we observed a low (always <10% and typically <2%) expression of PD-1, TIM-3 and LAG-3 on T cells from MM patients, while the expression of TIGIT on both CD4+ and CD8+ T-cell compartments was much more pronounced (Figure 3, panels B and C). The gene discussed is TIGIT; the disease is Miyoshi myopathy.