We present our findings on RANKL and WNT5A function in osteoclastogenesis and study the effect of the anti-gp130 antibody on RANKL and WNT5A in IL-6–stimulated RA FLS in vitro and in a collagen antibody–induced arthritis (CAIA) mouse model. The gene discussed is TNFSF11; the disease is arthritic joint disease.