Compared with the controls, the patients had higher gp130 expression, after 10-day induction by RANKL and GM-CSF; almost 60% of cells were osteoclasts, and the percentage of gp130-positive cells was significantly increased post-induction compared with pre-induction in both the control and RA groups (Figure 1I). This evidence concerns the gene CSF2 and rheumatoid arthritis.