Regarding these results and all the findings in G1, Huang et al. (2015) [30] reported in a murine 4T1 tumor model at the same late stage of development evaluated in our study, a high infiltration of CD4+ T cells, mainly composed of Tregs, as well as high CD4/CD8 and Treg/CD8+ T cell ratios. The gene discussed is CD8A; the disease is neoplasm.