Therefore, it is expected that PPP2R1A plays a crucial regulatoryrole in cell proliferation in cancer cell line(35).HSP90AA1 and CALM3 were found as two top ranked genes in the down-regulated PPI network.These proteins belong to family of proteins which involved in the regulation of specifictarget proteins in cell cycle control and programmed cell death (36, 37). This evidence concerns the gene CALM3 and cancer.