HSP90AA1 and cancer: Therefore, it is expected that PPP2R1A plays a crucial regulatoryrole in cell proliferation in cancer cell line(35).HSP90AA1 and CALM3 were found as two top ranked genes in the down-regulated PPI network.These proteins belong to family of proteins which involved in the regulation of specifictarget proteins in cell cycle control and programmed cell death (36, 37).