TARDBP and amyotrophic lateral sclerosis: The reduction of axonal growth may be due to (1) the gradual cytoplasmic accumulation of TDP-43, where the phenotype appears to correlate with ALS-linked mutations [74], and (2) destabilization of a microtubule-associated protein MAP1B/Futsch mRNA, which is bound and regulated by TDP-43 [75].