Curiously, TDP-43 pathology is also observed in diseases caused by mutations in the above genes [55], such as Alzheimer's disease (caused by mutations in APP and presenilins) and Huntington's disease (caused by the mutations in Huntingtin), further highlighting the potential cross-talk of TDP-43 with signature proteins of other neurodegenerative diseases and the critical roles of TDP-43 in the proper functions of the nervous system. This evidence concerns the gene TARDBP and neurodegenerative disease.