Indeed, dysregulations in common molecular players, including TARDBP [3, 4], FUS [5, 6], UBQLN2 [7], VCP [8], TBK1 [9–11], CHMP2B [12, 13], and expanded hexanucleotide repeats within the C9ORF72 gene [14, 15], contribute to both diseases, indicating that these ALS-FTD-linked genes can cause dysfunctions in both the motor system and cognition. The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.