Although UBE2L3 polymorphisms have been associated with seven AID (Ricaño-Ponce and Wijmenga, 2013), after applying our approach and considering the stringent genome-wide P-value threshold (P < 5 × 10−8), we found three AID (SLE, CD, and IBD) sharing association with UBE2L3, indicating deregulation of miRNAs pathways at least in these three diseases. Here, UBE2L3 is linked to systemic lupus erythematosus.