Besides 2B4 and NKG2D, DNAX accessory molecule 1 (DNAM-1) was also shown to be widely expressed in Vδ1+, Vδ2+, and Vδ1−Vδ2− γδ T cell subsets (64); and masking DNAM-1 on γδ T cells significantly inhibited tumor cell killing (64, 65). The gene discussed is CD226; the disease is neoplasm.