LPC treatment rapidly enhanced the phosphorylation of PI3K and p38 MAPK after 15 min of H37Ra infection in macrophages (Figure 2A), but the phosphorylation level of MEK1/2, ERK1/2, and JNK1/2 was decreased in LPC-treated cells infected with Mtb (Figure S1C in Supplementary Material). Here, MAPK8 is linked to infection.