PLA2G7 and atherosclerosis: It readily undergoes enzymatic oxidation by platelet-activating factor-acetylhydrolase (LP-PLA2) to yield immunogenic phosphorylcholine (PC) (58), an OSE that has been demonstrated to be an important inflammatory mediator in the setting of ASCVD, functioning through activation of T cells, monocytes, and endothelial cells following protein adduction (51, 59–63).