CASP3 and infection: However, caspase-3 inhibitor decreased both the intracellular VP1 expression from 1.00 ± 0.29 to 0.36 ± 0.21 (by 2.78-fold, P < 0.05), and the supernatant VP1 expression from 1.00 ± 0.14 to 0.21 ± 0.06 (by 4.76-fold, P < 0.001) at 24 h post-infection as assessed by Western blot assays (Figure 6E).