ADRB3 and obesity due to melanocortin 4 receptor deficiency: Other examples of nsSNPs reported to be associated with obesity included leptin (LEPR) rs1805094 (Lys656Asn) (12), beta-2 adrenergic receptor (ADRB2) rs1042714 (Glu27Gln) (13), beta-3 adrenergic receptor (ADRB3) rs4994 (Trp64Arg) (14), and vitamin D receptor (VDR) rs2228570 (Met1Thr) (15).