LEP and colorectal carcinoma: Serum HMW-ADPN levels in male OW/OB + CRC patients were significantly decreased by 37.5% (1.67 ± 1.05 vs. 2.68 ± 1.41 μg/mL, P < 0.05), while the leptin levels were significantly increased by 86.1% (2.22 ± 1.29 vs. 1.20 ± 1.36 ng/mL, P < 0.01) when compared with NW + CRC patients.