After stratifying all subjects into trisections according to serum leptin tertiles, the probability of CRC risk was found to decrease by 94.0% in subjects with the highest leptin level compared to those with the lowest serum leptin levels after adjusting for age, gender, BMI, SBP, DBP, and FBG (Model 2, OR = 0.06). This evidence concerns the gene LEP and colorectal carcinoma.