LEP and colorectal carcinoma: As shown in Figures 1E–H, serum HMW-ADPN levels in OW/OB + CRC patients were significantly decreased by 23.5% (2.02 ± 1.19 vs. 2.64 ± 1.30 μg/mL, P < 0.05), while the leptin levels were significantly increased by 57.7% (2.87 ± 1.47 vs. 1.82 ± 1.90 ng/mL, P < 0.01) when compared with NW + CRC patients.