As presented in Table 4, the probability of CRC risk decreased by 94.0% in participants with the highest leptin level compared with those with the lowest serum leptin levels (OR = 0.06, 95% CI 0.01–0.41, P = 0.01) after adjusting for age, gender, BMI, SBP, DBP, and FBG (Model 2). The gene discussed is LEP; the disease is colorectal carcinoma.