TNF and colorectal carcinoma: Our results showed that ZAG mRNA levels in sWAT were significantly lower in OB + CRC patients than in NW + CRC patients (reduced by 78.8%, P < 0.01) as presented in Figure 2A. Additionally, TNF-α mRNA levels in vWAT of OB + CRC patients were significantly increased by 2.8-fold when compared with NW + CRC patients (P < 0.05) (Figure 2H).