Notwithstanding, the presence of independent associations between a prognostic indicator of CM (i.e., Breslow index), and a measure of OSA severity (i.e., DI4%) as explaining the variance in HIF-1α expression abundance suggest that the presence of OSA and its severity may contribute to the malignant characteristics of CM, and play a deleterious role in the outcomes of this highly prevalent tumor. The gene discussed is HIF1A; the disease is neoplasm.