On the basis of these criteria 116 patients were diagnosed as HS and 86 as hemolytic anemias other than HS: 15 HE, 9 HSt (6 PIEZO1 and 3 KCNN4 variants), 37 erythroenzymopaties (27 PK, 4 P5′N, 1 TPI, and 5 GPI deficiency), 16 CDAII. Here, PIEZO1 is linked to histiocytic sarcoma.